RXR Agonists Enhance Lenalidomide Anti-Myeloma Activity and T Cell Functions while Retaining Glucose-Lowering Effect Jian Wu, Xiaobei Wang, Min Zhang, Parker Mathews and Yubin Kang. Cells, 3 August 2023, doi: 10.3390/cells12151993
IRX4204 Induces Senescence and Cell Death in HER2-positive Breast Cancer and Synergizes with Anti-HER2 Therapy Cassandra L. Moyer, Amanda Lanier, Jing Qian, Darian Coleman, Jamal Hill, Vidyasagar Vuligonda, Martin E. Sanders, Abhijit Mazumdar, and Powel H. Brown. Clinical Cancer Research, 30(11) June 1, 2024, American Association for Cancer Research
Preserving and enhancing mitochondrial function after stroke to protect and repair the neurovascular unit: novel opportunities for nanoparticle-based drug delivery Robyn J. Novorolsky, Gracious D. S. Kasheke, Antoine Hakim, Marianna Foldvari, Gabriel G. Dorighello, Israel Sekler, Vidyasagar Vuligonda, Martin E. Sanders, Robert B. Renden, Justin J. Wilson, & George S. Robertson. Frontiers in Cellular Neuroscience, 7 July 2023, doi: 10.3389/fncel.2023.1226630
Targeting the Retinoid X Receptor Pathway Prevents and Ameliorates Murine Chronic Graft-Versus-Host Disease Govindarajan Thangavelu, Michael C. Zaiken, Fathima A. Mohamed, Ryan Flynn, Jing Du, Stephanie Y. Rhee, Megan J. Riddle, Ethan G. Aguilar, Angela Panoskaltsis-Mortari, Martin E. Sanders, & Bruce R. Blazar. Frontiers in Immunology, 11 March 2022, doi: 10.3389/fimmu.2022.765319
Repurposing a novel anti-cancer RXR agonist to attenuate murine acute GVHD and maintain graft-versus-leukemia responses Govindarajan Thangavelu, Chao Wang, Michael Loschi, Asim Saha, Mark J. Osborn, Scott N. Furlan, Kazutoshi Aoyama, Cameron McDonald-Hyman, Ethan G. Aguilar, Amanda S. Janesick, Roshantha A. Chandraratna, Yosef Refaeli, Angela Panoskaltsis-Mortari, Kelli P. MacDonald, Geoffrey R. Hill, Robert Zeiser, Ivan Maillard, Jonathan S. Serody, William J. Murphy, David H. Munn, Bruce Blumberg, Chrysothemis Brown, Vijay Kuchroo, Leslie S. Kean, Keli L. Hippen, Randolph J. Noelle, & Bruce R. Blazar. Blood®, 25 February 2021, Vol 137, No 8, The American Society of Hematology
Treatment with retinoid X receptor agonist IRX4204 ameliorates experimental autoimmune encephalomyelitis Chandraratna RA, Noelle RJ, Nowak EC. American Journal of Translational Research, 2016, 8(2):1016-1026, ISSN:1943-8141/AJTR0022086, www.ajtr.org
Selective brain penetrable Nurr1 transactivator for treating Parkinson’s disease Jun Wang, Weina Bi, Wei Zhao, Merina Varghese, Rick J. Koch, Ruth H. Walker, Roshantha A. Chandraratna, Martin E. Sanders, Amanda Janesick, Bruce Blumberg, Libby Ward, Lap Ho, and Giulio M. Pasinetti. Oncotarget, February 2016, Vol 7, No 7, 7(7):7469-79, doi: 10.18632/oncotarget.7191.PMID: 26862735
Triterpenoids CDDO-Methyl Ester or CDDO-Ethyl Amide and Rexinoids LG100268 or NRX194204 for Prevention and Treatment of Lung Cancer in Mice Karen Liby, Renee Risingsong, Darlene B. Royce, Charlotte R. Williams, Tian Ma, Mark M. Yore, & Michael B. Sporn, Cancer Prevention Research, December 2009, 2(12)
A New Rexinoid, NRX194204, Prevents Carcinogenesis in Both the Lung and Mammary Gland Karen Liby, Darlene B. Royce, Renee Risingsong, Charlotte R. Williams, Matthew D. Wood, Roshantha A. Chandraratna, and Michael B. Sporn, Clinical Cancer Research, 15 October 2007, 13(20), American Association for Cancer Research
Retinoic acid receptor 𝛼 and retinoid X receptor specific agonists reduce renal injury in established chronic glomerulonephritis of the rat Matthias Schaier, Sabine Liebler, Kerstin Schade, Fujio Shimizu, Hiroshi Kawachi, Hermann-Joseph Grone, Roshantha Chandraratna, Eberhard Ritz, Juergen Wagner, Journal of Molecular Medicine, 8 January 2004, DOI 10.1007/s00109-003-0510-3
Enantioselective Syntheses of Potent Retinoid X Receptor Ligands: Differential Biological Activities of Individual Antipodes Vidyasagar Vuligonda, Scott M. Thacher, & Roshantha A. S. Chandraratna, Journal of Medical Chemistry, 2 June 2001, Vol 44, No 14, 2298–2303, American Chemical Society